However, studies have used mainly brief cognitive tests or online surveys, which are not designed to characterize the neuropsychological profile associated with COVID-19 ( Daroische et al., 2021). To date, heterogeneous findings have been found in several cognitive domains, especially concerning attention and executive functioning and episodic memory ( Almeria et al., 2020 Woo et al., 2020 Zhou et al., 2020). Evidence regarding the prevalence, characteristics, and mechanisms associated with cognitive dysfunction after COVID-19 is still scarce ( Daroische et al., 2021). Specifically, cognitive issues are among the most frequent neurological symptoms reported by patients after the acute phase ( Bliddal et al., 2021 Vanichkachorn et al., 2021). Post-acute manifestations are included under the umbrella terms of post-COVID-19 syndrome or long-COVID-19 and are relatively common after Coronavirus Disease-2019 (COVID-19 Hellmuth et al., 2021 Nalbandian et al., 2021). The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can affect multiple organs and tissues, including the central nervous system. The investigation of neurodegenerative processes in an early stage, especially in older patients, is probably warranted. A detailed assessment combining clinical, cognitive, and biomarker studies may help disentangle the underlying mechanisms associated with cognitive dysfunction in each case. Our case highlights the need to examine patients with cognitive symptoms following COVID-19 comprehensively. 4Department of Nuclear Medicine, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Universidad Complutense, Madrid, SpainĬognitive symptoms after COVID-19 have been increasingly recognized several months after the acute infection and have been designated as “brain fog.” We report a patient with cognitive symptoms that started immediately after COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer’s disease.3Institute of Laboratory Medicine, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Universidad Complutense, Madrid, Spain.2Department of Radiology, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Universidad Complutense, Madrid, Spain.1Department of Neurology, Institute of Neuroscience, Hospital Clinico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Universidad Complutense, Madrid, Spain.Matias-Guiu 1 * Cristina Delgado-Alonso 1 Miguel Yus 2 Carmen Polidura 2 Natividad Gómez-Ruiz 2 María Valles-Salgado 1 Isabel Ortega-Madueño 3 María Nieves Cabrera-Martín 4 Jorge Matias-Guiu 1
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